Abatacept (ORENCIA) ELISA Kit

Abatacept (ORENCIA) ELISA Kit Abatacept is a recombinant fusion protein that modulates the immune response by selectively inhibiting T-cell activation. It functions as a CTLA-4-Ig fusion protein, which binds to CD80/CD86 on antigen-presenting cells (APCs), thereby preventing the necessary co-stimulatory signal (CD28-CD80/86) for full T-cell activation. Abatacept is often studied in relation to immunological biomarkers—such as T-cell subsets, cytokine profiles, and autoantibodies—which reflect its biological activity and treatment response in autoimmune diseases. Clinically, abatacept is approved for rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and psoriatic arthritis, where it serves as a second-line or biologic disease-modifying antirheumatic drug (bDMARD). It is particularly useful in those with inadequate response to TNF inhibitors. In research settings, abatacept is used to probe mechanisms of T-cell tolerance, co-stimulatory signaling, and autoimmune pathogenesis. Studies often use it as a tool to investigate biomarker-guided treatment strategies, including prediction of response via baseline levels of autoantibodies (like RF or anti-CCP), T-cell phenotypes, or gene expression signatures. Its immunomodulatory properties also make it a candidate for exploring therapeutic interventions in type 1 diabetes, lupus, and organ transplant rejection. This Abatacept (ORENCIA) ELISA Kit is manufactured in Turkey by Matriks Biotek. Size Sensitivity 3 ng/mL Dynamic Range 3-100 ng/mL Incubation Time 105 minutes Sample Type Serum, Plasma Storage 2-8°C Alternative Names Orencia®,CTLA4-Ig, CTLA-4 immunoglobulin fusion protein, selective T-cell co-stimulation modulator, costimulation blocker, bDMARD Instructions For Use MSDS   Related products Anti-Cardiolipin Screen ELISA Kit SKU: DKO144 $535.00 Inquire Anti-Beta2 Glycoprotein 1 IgM ELISA Kit SKU: DKO111 $500.00 Inquire Anti-dsDNA IgG ELISA Kit SKU: DKO095 $550.00 Inquire Anti-Tissue Transglutaminase (tTG) IgG ELISA Kit SKU: DKO109 $685.00 Inquire