ADMA (Asymmetric Dimethylarginine) / Arginine ELISA Kit

ADMA (Asymmetric Dimethylarginine) / Arginine ELISA Kit Asymmetric dimethylarginine (ADMA) and L-arginine are key biomarkers involved in the regulation of nitric oxide (NO) production, a critical mediator of vascular structure and function. NO is synthesized in the endothelium from L-arginine by the enzyme nitric oxide synthase (NOS), and plays a vital role in maintaining vascular homeostasis, earning its designation as an “endogenous anti-atherogenic molecule.” ADMA, an endogenous NOS inhibitor, impairs NO synthesis by competing with L-arginine for NOS binding sites, thereby disrupting endothelial function and promoting vascular dysfunction. Elevated levels of ADMA have been linked to various cardiovascular and metabolic disorders, including hypertension, hypercholesterolemia, chronic heart failure, and renal disease. Clinical studies involving over 10,000 participants have identified high ADMA concentrations as a significant risk factor for cardiovascular events and all-cause mortality. Additionally, the L-arginine/ADMA ratio has emerged as a more accurate indicator of NOS pathway functionality than L-arginine levels alone. This ratio reflects the balance between substrate availability and enzymatic inhibition, making it particularly relevant in both research and clinical settings. In practice, simultaneous measurement of L-arginine and ADMA plasma concentrations provides valuable insight into endothelial function, vascular risk, and the efficacy of therapeutic interventions, such as nutritional L-arginine supplementation. The inclusion of ADMA and the L-arginine/ADMA ratio as biomarkers supports early disease detection, patient stratification, and monitoring of treatment outcomes in cardiovascular and renal health research. This ADMA (Asymmetric Dimethylarginine) / Arginine ELISA Kit is manufactured in Germany by DLD Diagnostika. Size Sensitivity 0.03 µmol/L Dynamic Range ADMA: 0.2 – 3.0 µmol/L, Arginine: 5 – 300 µmol/L Incubation Time 3 hours Sample Type EDTA Plasma, serum Storage 2-8°C Alternative Names Asymmetric dimethylarginine, NG,NG-dimethyl-L-arginine, dimethylated arginine derivative, endogenous NOS inhibitor, methylated arginine analog, arginine methylation product, NOS pathway inhibitor, dimethylarginine metabolite, vascular NO synthesis inhibitor, ADMA biomarker. Instructions For Use MSDS   Related products Complement Factor P Quantitative Assay Kit SKU: COMPL FPQ RUO $925.00 Inquire Total complement functional screen ELISA Kit SKU: COMPL 300 RUO $970.00 Inquire Complement Factor P Functional Assay Kit SKU: COMPL FPF RUO $1,535.00 Inquire Anti-PR3 (c-ANCA) ELISA Kit SKU: DKO091 $700.00 Inquire